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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

PROSTEOSTASIS team

Team Leader : Pierre Fafournoux

equipe FRM
logo FRM

Topics and objectives

Many diseases as well as aging are often associated with disturbances of amino acid/protein metabolism. This contributes to the occurrence of a catabolic state leading to muscle loss that worsens health and decreases the effectiveness of treatments. We are studying amino acid/protein homeostasis in order to understand the origins and consequences of these dysregulations. The ultimate goal is to develop nutritional and/or pharmacological strategies promoting the maintenance of amino acid homeostasis, focusing our research on the following points:

1) The characterization of the molecular mechanisms involved in the adaptive response to variations in amino acid availability; 2) the regulation of proteosynthesis and proteolysis in tissues; the inter-organ relationships in the use of amino acids.

           

Key-words

Amino acid availability

Muscle loss

Signaling and gene expression

Ubiquitin-Proteasome System

Autophagy

Mitochondrial homeostasis

Inter-organ relationships

The counter-model of hibernating bear

Aging

Fetal programing

Health biomarkers

Nutritional strategies

Control of gene expression in gene therapy

Research Program

♦ Understand: Characterization of molecular mechnisms involved in the regulation of amino acid/protein homeostasis
Prevent and predict: From markers of muscle wasting and protein malnutrition to interventional strategies for preserving organs functions
Tackle: Improving patient health by correcting amino acid/protein homeostasis in chronic diseases
Transfer of the research finding to gene-therapy

Our research activities concern the following themes :

Nutrition_Cells_EN
Bone_Muscle_EN
Plant Food_EN

Key-words

Topics
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