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Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Mechanisms of action of plant food bioactives

Mechanisms of action of plant food bioactives
To unravel the complexity of mechanisms underlying the vascular protective effects of plant food bioactives

Our group has put significant efforts during the last years to develop integrated approaches associating in vivo experiments (animal or human nutritional intervention) and high-throughput omic tools (transcriptomics, proteomics and lipidomics). This allowed us to identify the food bioactives (polyphenols and their metabolites, long chain PUFAs and oxylipins) responsible for the vasculoprotective effects of selected foods as well as key target cellular processes of these bioactives controlling vascular integrity and inflammation. Our main objective now is to progress in the understanding of the intimate cellular and molecular mechanisms of action of the most relevant bioactives. On the basis of the most prominent results obtained from preclinical and clinical studies, and more recently from in vitro experiments, our research will mainly concentrate on the impact of flavonoid metabolites and oxylipins on the cascade leading to monocyte infiltration into the vascular wall and to vascular inflammation. This part of our project focused on mechanistic investigations will be performed using relevant metabolites of selected bioactives studied at nutritionally achievable concentrations in the circulation. These fundamental studies will also have an applied outcome by helping to develop tailored experimental strategy for evaluating vasculoprotective effects of a variety of plant food bioactives of interest.

1. Ascertain the effects of bioactives on endothelial and monocytes/macrophages functions and their interactions

  • Impact on the interaction between endothelial cells and monocytes
  • Impact on macrophages inflammatory response and polarization

2. Interplay of food bioactives on cell metabolism, signalling and gene expression pathways

  • Interaction of plant food bioactives with cell signalling pathways
  • Effects of bioactives on PUFA metabolism
  • Deciphering the complexity of the nutri(epi)genomic effects of plant food bioactives mediating their impact on endothelial cell functions