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Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Identification de biomarqueurs de santé, modulables par l’alimentation

Identification de biomarqueurs de santé, modulables par l’alimentation
Identification de biomarqueurs de santé, modulables par l’alimentation

There is an urgent need to find reliable biomarker patterns that characterize the trajectory from health to disease allowing intervention before irreversible damage develops while assessing the efficacy of dietary intervention. The NutriVasc Team is involved in several projects in the field of biomarkers of nutrition and cardiometabolic health.

Illustration Id biomarkers santé

In the NUTREND project (INRA Métaprogramme DID’IT), we aim to gain a comprehensive picture of the endothelium phenotype by developing and combining new functional and circulating biomarkers of vascular reactivity and integrity that could be easily transferable to cohorts. Especially, we aim at evaluating the potency of Hyperemic velocity (VTI), circulating endothelial microparticules and specific microRNAs to reveal endothelial dysfunction in healthy individuals and to determine their ability to discriminate healthy individuals from dysmetabolic subjects.

In the JPI-HDHL OXYGENATE project, we hypothesized that targeted lipidomic profiling of oxylipins could provide relevant candidate biomarkers of cardiometabolic syndrome. Our main objective is to uncover and validate the oxylipin signatures reflecting the trajectory from health to cardiometabolic syndrome and its relationships with diet.

Key-words: biomarker, dietary intervention, vascular reactivity, endothelial microparticules, microRNAs, lipid mediators, oxylipins, cardiometabolic syndrome.