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Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Identification de biomarqueurs d’exposition - Food Metabolome

Identification de biomarqueurs d’exposition - Food Metabolome
Exploration of food metabolome in human intervention studies

The inventory of all phytochemicals commonly present in foods, realized for the development of PhytoHub database, revealed that individuals are exposed to hundreds of phytochemicals potentially active but still not studied for their contribution to the health effects of their food sources. Terpenes in particular may deserve more attention as they are well absorbed and often found in our studies as important components of the urine metabolome after plant food intake. Their complex chemistry may have discouraged the investigation of their health effects, although they are considered as active principle in many medicinal plants. The Food metabolome research activity settled within our team gives us a unique opportunity to build relevant and competitive projects on plant foods and bioactives aiming to identify new bioactives related to the consumption of specific foods and potentially involved in their vascular protective effects. Two types of analytical methods currently exist for plant food bioactives in biofluids. The first ones are targeted methods for specific compounds, which are ideal for quantification but inadequate for discovering new bioactive compounds. The second ones are non-targeted metabolomics methods, prone to reveal new putative bioactives, but suffering from insufficient characterization of their chemical coverage and from the difficulty to identify all detected metabolites. We will use a new semi-targeted metabolomics approach based on high resolution mass spectrometry (LC and GC-QTof), covering the range of masse, polarities, and ionisations of all families of plant food bioactives and their human metabolites. A large panel of standards of food bioactive metabolites, as well as urine and plasma samples from rats fed isolated food bioactives will be analysed using this method to generate an in-house spectral library allowing automatic identification of a wide range of metabolites of plant food bioactives in metabolomics profiles. Using this analytical approach and the database PhytoHub, we will have a unique expertise to acquire and interpret comprehensive profiles of individual’s exposures to plant bioactive metabolites. The cross analysis of these annotated profiles with the vascular responses observed in our human intervention studies may bring to light new bioactives potentially interesting for vascular protection. The kinetics parameters and interindividual variations will be considered for that purpose. The approach may also be used to monitor the impact of factors such as food processing on the resulting exposure of consumers to bioactive compounds and relate the variations with variations observed in health effects. The potency of the newly identified putative bioactives to exhibit vascular protective properties could be further assessed in preclinical studies.