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Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Diet, Plant food bioactives & Vascular Health

Team leader : Christine Morand

Research

Maintaining vascular function is essential in preserving health and healthy aging. Early vascular dysfunction is associated with initiation of atherosclerosis, CVD development and contributes to the occurrence of type 2-diabetes and cognitive decline. Therefore, it is of great importance to identify innovative and scientifically sound dietary strategies to prevent vascular dysfunctions. Evidence from large prospective cohort studies have pointed out that dietary bioactive plant compounds contribute to the cardiovascular protective effects of diets rich in plant foods.

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However, the actual impact of most of these compounds in human and their mechanisms of action have not yet been fully established. In this context, using a translational approach and combining classical and "omics" methodologies, the research of the NutriVasc team focuses on understanding the role of plant food bioactives in the prevention of vascular dysfunctions, with as major objectives:

NutriVasc News'

Actus Illustration

Keywords

Biomarkers exposure and health

Polyphenols

Oxylipins and lipid mediators

Vascular function and endothelium

Dietary plant food bioactives

Targeted lipidomics

Food Metabolome

Nutrigenomics

Clinical trials

1. Provide clinical evidence of the role of bioactive compounds (polyphenols, phytoprostans) in the prevention or delay of vascular dysfunction and unravel the complexity of the underlying cellular and molecular mechanisms of action

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2. Characterize the complexity of the individual exposure to plant bioactive metabolites by the Food Metabolome approach

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3. Identify the main determinants of inter-individual variation in the response to the consumption of plant food bioactives (bioavailability and vascular protective effects).

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                       FoodMetabolome                       Variabilite_Interindividuelle                       mecanismes                       biomarqueurs-modulables

Click on the figure to obtain more details on our research.

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Transversal research

Plant Food_EN