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Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Micro-Environnement CellulaiRe, Immunomodulation et Nutrition

Team leader : Florence CALDEFIE-CHEZET

Research objective

The main objective of our team is to characterize the response of immunocompetent cells (ICCs) to their microenvironment variations. It is part of the field of immunonutrition with two major objectives:

1) Identify the relationships between immune / inflammatory alterations and metabolic disorders related to nutritional and immune status in physio-pathological conditions (notably aging, cancer). In this context, our research focuses more specifically on interactions between mammary epithelial cells (immunocompetent barrier cells) and their microenvironment (adipocyte, immune and inflammatory) with obesity, considered as a risk factor for breast cancer.

2) Maintain / optimize the response of ICCs through nutritional interventions with preventive and / or therapeutic approach. For this, modulation of the interaction between the ICCs and the other cells (breast, intestine, muscles) is developed using immunomodulatory food bioactives (pre and probiotics, vitamin D, plant bioactives), in order to prevent the risk of chronic pathology associated with aging.

Our work is conducted with a transversal approach using both experimental original cell (2 and 3D) and animal models (hypercaloric regime, enriched environment) and clinical research protocols.

Keywords

Aging, obesity, immunocompetent cells, microenvironment, adipocytes, food bioactives, probiotics, phytochemistry, cell and animal models, clinical studies.

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