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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Dr Alexandre PINEL

Activities

Email: contact
Tel: +33 (0)4 73 60 82 80

Dr Alexandre PINEL

Nutrition plays a major role in the prevention of physiopathologies such as obesity and sarcopenia. My PHD training was related to Nutrition and the role of omega-3 polyunsaturated fatty acids in metabolic alterations associated with obesity and insulin resistance. The aim was to compare the effects of omega-3 fatty acids (ALA, EPA and DHA) on adipose tissue and muscle metabolisms. As research engineer, I tried to explore the cross-talk between adipocytes and muscle cells and the effect of adipocyte insulin-resistance in this context. Through my research, I want to explore mechanisms and mediators involved in the dialogue between tissues to better understand their respective role in metabolic disorders related to obesity and sarcopenia. In september 2018, I have been recruited as assistant professor. I want to bring to the laboratory new approaches and theoretical aspects on Nutrition and cross-talk between tissues and to be innovative both in research and teaching.

Research Activities

During sarcopenia, the body composition is modified, with an increase in fat mass and a proportional decrease in lean mass (mainly muscle mass). Then metabolic alterations could be observed such as insulin resistance and low-grade inflammation. Mediators secreted by adipose and muscle cells might be involved in these alterations. Less is known about their effects on both adipocytes and muscle cells and the potential effects of nutritional strategies on their secretion. In the laboratory, I'm focusing my work on these points by developping co-culture and conditioned media assays to evaluate the cross-talk between adipocytes and differentiated muscle cells. Purification of mediators involved (miRNA, exosomes, lipids and proteins) would be realized to explore their role in metabolic alterations. These aspects are complementary to the expertise of the laboratory in terms of protein and lipid metabolisms. A first study we published demonstrated that secretion of insulin-resistant adipocytes was able to induce insulin resistance in differentiated skeletal muscle cells in vitro.

Publications

  • Pinel, A., Rigaudière, J-P., Jouve, C., Capel F. (2018). Modulation of Insulin Resistance and the Adipocyte-Skeletal Muscle Cell Cross-Talk by LCn-3PUFA. Int J Mol Sci.
  • Pinel, A., Pitois, E. et al. (2016). "EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet." J Lipid Res.
  • Pinel, A., Rigaudiere, J-P., et al. (2015). "N-3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells." Biochim Biophys Acta.
  • Pinel, A., Morio-Liondore, B., Capel, F. (2014) N-3 Polyunsaturated fatty acids modulate metabolism of insulin-sensitive tissues: implication for the prevention of type 2 diabetes. J Physiol Biochem.

Curriculum Vitae

Since September 2018: assistant professor, INRA/UCA, Unité de Nutrition Humaine, Clermont-Ferrand, France

Teaching in :

UFR Médecine et Professions paramédicales, Université Clermont Auvergne, Clermont-Ferrand. 2ème année Diplôme Universitaire de Technologie, Génie Biologique, Option Diététique; 2ème année du Diplôme de Formation Générale en Sciences Médicales (DFGSM2); 3ème année de Licence Sciences, Technologies, Santé, mention Sciences pour la Santé parcours Nutrition; Master Biologie Santé parcours Nutrition, Santé, Innovation; Diplôme Universitaire Nutrition, Agression, Maladies Chroniques.

2017-18: Attaché temporaire d'enseignement et de recherche, Université Clermont Auvergne, France.

2015-17: Research Engineer, INRA/UCA, Unité de Nutrition Humaine, Clermont-Ferrand, France

2012-15: PhD, INRA/UCA, Unité de Nutrition Humaine, Clermont-Ferrand, France