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24, chemin de Borde Rouge –Auzeville – CS52627
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Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

'HIBERNATUS' Projet I-site Clermont 2019-2020

05 November 2018

Le modèle de l’ours hibernant dans la lutte contre l’atrophie musculaire chez l’homme - Coordinateur: Etienne Lefai

Ce projet vise à développer de nouveaux outils dans la lutte contre l’atrophie musculaire chez l’homme, problème majeur de santé publique qui réduit l’autonomie et participe à la dégradation du métabolisme. A la différence des modèles murins habituels, nous explorons les mécanismes qui permettent à l’ours brun de préserver sa masse musculaire durant les périodes d’hibernation (jusqu’à 7 mois). Nous venons de démontrer que le sérum d’ours en hiver possède des propriétés hypertrophiques sur des cultures de cellules musculaires humaines, en limitant la dégradation des protéines. L’objectif principal de ce projet est de déterminer comment des fractions ou des composés actifs présents dans le sérum d’ours hibernant peuvent prévenir et / ou reverser des situations d’atrophie induite dans des modèles in vitro.

Programme financé à hauteur de 38 k€ sur 18 mois (2019-2020)