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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée


01 January 2019

Study of the potential links between the endocannabinoid system, the ectopic accumulation of lipids in skeletal muscle, the development of anabolic resistance and the loss of muscle mass/function in sarcopenic obesity.

Financial support from the Auvergne-Rhône-Alpes region as part of the scientific challenge 3 of I-SITE program (2019-2020): personalized mobility as a key factor of health. Coordinator : Olivier Le Bacquer.

Sarcopenic obesity is a muscle loss that occurs in the context of excessive obesity in aged people. The endocannabinoid system controls food intake, but also lipid and glucose homeostasis in the liver and adipose tissue. In skeletal muscle, it controls muscle differentiation and insulin sensitivity. Our preliminary results show that the endocannabinoid system regulates protein synthesis in an in vitro model of myotubes. In the current project, we are targeting the endocannabinoid system to reduce muscle lipotoxicity and anabolic resistance of protein homeostasis in skeletal muscle. We will characterize 1) alterations of the endocannabinoid system associated with aging and 2) in a model of induced sarcopenic obesity, the effect of blocking the endocannabinoid system on the ectopic accumulation of lipids in skeletal muscle and the resulting anabolic resistance.