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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Human Nutrition Unit

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New databases on food compounds and food metabolome to support discovery of novel dietary biomarkers

The quantification of food intake is an important part of nutrition studies, normally done using food frequency questionaires. Unfortunately, this method is prone to under or overreporting of food intake, compromising the interpretation of results in many cases. Markers of food intake are the best alternative to overcome this problem as they provide a direct measure of food consumption, allowing more accuracy in nutrition cohorts. So far, only few food items are covered by validated biomarkers of intake and the discovery of novel markers is necessary to push nutrition research forward. The present proposal is part of a JPI Healthy Diet for Healthy Life-funded project – FoodBall (Food Biomarkers Alliance, 22 partners, 2014-2017) aiming to develop the missing tools and resources to facilitate the identification of biomarkers of food intake using metabolomics. It includes the main tasks described below: Construction of a database on food metabolome:
The database will contain chemical and biochemical data on all known dietary compounds, the foods where they are found as well as their concentration. It will include both known (reported in the literature) and in silico predicted human metabolites of dietary compounds. Development of a library for food-derived metabolites: A new chemical library will be created including standards for food compounds and their metabolites as well as directories of laboratories where these standards may be obtained. Food compound metabolites will also be directly obtained through in vivo biotransformation of specific food constituents. Reference MS and NMR spectral information will be collected and made available.The tools described above will be available to the scientific community through a public web portal which will also include any further information considered useful or that may facilitate the identification and use of dietary biomarkers and the interaction of the different groups. Link: (UNH contact C. Manach)