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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Research Projects


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Lacto for Health

Nutritional strategy to reduce sarcopenia in the under nourished elderly: enrichment of a food in probiotics "energy saver"

Coordinator: Isabelle Savary-Auzeloux (Team Improving)
ANR Melodies

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Determination of organ-specific biomarkers of diabetes using a novel quantitative metabolomics approach:  the liquid metabolic biopsy concept

Coordinator: Sergio Polakof (Team Improving)
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Controlling infectious disease by modulating the microbiota with an implantable device.

Collaborateur: Didier Rémond (Equipe iMPROVINg)




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Development of food matrices based on fruit pastes as vectors of proteins or carbohydrates for the prevention and management of protein-energy malnutrition in the elderly.

Coordinator: Dominique Dardevet (Team Improving)



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Efficiency of food protein production in humid tropics: a trade-off among farms, plants and animals


Project in collaboration with:



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Valuing the plant proteins as blends of high nutritional quality for specific populations. Proof of concept with a new product designed for preventing metabolic dysfunctions in the elderly

Project in collaboration with:

INRA/UCA-UMR1019 UNH (coordination), INRA/AgroParisTech-UMR 0914 PNCA, Tereos Starch & Sweeteners Europe, General Mills-Yoplait 

Axe 3

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Skeletal Muscle Magnesium Transporters Gene Expression Responsiveness to Low Magnesium Status

Daniel Béchet

Project in collaboration with 

IDEX/I-SITE 2017 of « Programme investissement d’avenir 2, PIA 2 »

La mobilité personnalisée comme facteur clé de la santé (Mobinauv)

Emergence 2017

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Quantitative Metabolomics : a new approach to explore tissue metabolisms

Sergio Polakof

Project in collaboration with CEA (Paris Saclay)  and Toxalim  (Toulouse)

IDEX/I-SITE 2017 of « Programme investissement d’avenir 2, PIA 2 »

La mobilité personnalisée comme facteur clé de la santé (Mobinauv)



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Development of a new gene expression system modulated by a nutritional intervention that can be used in gene therapy

Pierre Fafournoux


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Optimization of the muscle mass preservation by a chrono-nutrition dissociated from the meal. Frail elderdies as a model.

Project in collaboration with  the Saint-Etienne Hospital and  Geriatrics institutions of the  Mutualité de la Loire.

Nutravita, Céréales Vallée,  Terralia

Coordinators: S. Polakof,  D. Dardevet  et D. Béchet 

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Development of a functional food with  Streptococcus thermophilus  to counteract intestinal inflammation

Aims of the project:

  • Test the probiotic potential of Streptococcus thermophilus  in acute and chronic induced colitis . 
  • Impact of Streptococcus thermophilus in the low grade inflammation induced sarcopenia  in the aging rat.

Researh units part ofthe project:
UNH - INRA ( D. Dardevet, I. Savary-Auzeloux )
Micalis – INRA (JM. Chatel, C. Cherbuy )

Plantes médicinales du territoire Auvergne

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Plantes médicinales du territoire Auvergne           

L’objectif du projet Plantinauv est de:
1) Valoriser le patrimoine botanique local en identifiant des plantes d’intérêts alimentaire et médicinal.
2) Apporter des preuves chimiques et biologiques supportant les effets bénéfiques des espèces végétales d’intérêt.
3) À terme, permettre leur commercialisation sous la forme d’ingrédients actifs /produits.
Unités impliquées: UNH-Clermont (Equipe ECREIN, F. Caldefie-Chezet), Sigma Clermont (Equipe COM, P. Chalard), Cluster Nutravita.

Projet MicroNut


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Impact de la structure des aliments sur la biodisponibilité des micronutriments

L’objectif du projet MicroNut est de déterminer :
1) l’impact de la structure / texture d’un aliment sur la biodisponibilité en micronutriments (vitamines B12, B9, D, caroténoïdes) chez l’homme adulte : de la mastication, digestion/absorption à la biodisponibilité plasmatique.
2) A terme : Apporter des critères rationnels pour aider au développement et la conception d’aliments à visée nutritionnelle spécifique.
Unités impliquées: STLO-Rennes (F Nau), UNH-Clermont/Theix (MA Peyron, I Savary-Auzeloux, D Rémond), UEN-CRNH Auvergne (R Richard), SQPOV (C Caris-Veyrat, E Reboul).



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Oxylipins signature to monitor the cardiometabolic status and its response to dietary intervention

 Project in collaboration with Dr A Astrup & L H Larsen, UCPH, Denmark; Analytical chemistry/lipidomics: Dr N Schebb, Univ. Wuppertal, Germany, Dr J Newman, USDA, Davis, CA, USA; Nutritional epidemiology and cardiometabolic health: Dr M Touvier, INSERM, France, Dr A Szuba, Medical Univ. Wroclaw, Poland.

Coordinator’s e-mail address:       

MaNuEL creates a network of dedicated scientists to build better research capacity on malnutrition across Europe.


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Malnutrition  in the Elderly                             

 MaNuEL creates a network of dedicated scientists to build better research capacity on malnutrition across Europe.
The project is led by Knowledge Hub coordinators Prof. dr. Ir Marjolein Visser (VU Medical Center Amsterdam, The Netherlands) and Dorothee Volkert (Friedrich Alexander University Erlangen- University of Erlangen-Nuremberg, Germany). This Knowledge Hub starts early 2016.

Collaboration between 7 countries : Austria, France, Germany, Ireland, Spain, the Netherlands en New Zealand.
UNH contact:  D. Dardevet)

Qualiment InProbiAuS


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Modulation du processus d’autophagie  par des probiotiques pour lutter contre les stress liés au vieillissement

Contacts UNH : L Combaret, A Bruhat, AC Maurin

Identification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing/reversing cognitive decline (D-CogPlast)


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Identification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing/reversing cognitive decline (D-CogPlast)

Aim of this project is to study associations between individual exposure to food-derived metabolites and cognitive decline, in 200 individuals with accelerated cognitive decline over 13 years against 200 control individuals"

Project in collaboration with IE, FR, DE, IT, NL, UK, DE, ES, AU, PL

UNH contact C. Manach



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« Vers une offre Alimentaire Adaptée et Saine à destination des populations SeniorS »

 ANR AlimaSsens en cours (edition 2014)

Contact UNH : MA Peyron ; Collègues iMPROVINg : I Auzeloux




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New databases on food compounds and food metabolome to support discovery of novel dietary biomarkers - FoodBall

The quantification of food intake by biomarkers of food intake (Food Biomarkers Alliance, 22 partners, 2014-2017)

Construction of a database on food metabolome and  Development of a library for food-derived metabolites

Link: (UNH contact C. Manach)