Dr Didier REMOND
Email : contact
Tel : +33(0)4 73 62 40 74
Demographic changes and increased life-span in western countries have resulted in a progressive ageing of populations. One of the major features of ageing is sarcopenia, which is a physiological and involuntary loss of muscle mass and strength. This feature is common to all older individuals, including healthy ones, and is considered to be one of the most important causes of disability, frailty and morbidity in the senior population. Therefore, preventing muscle protein mass loss in specific population contributes to maintain autonomy and healthy conditions and to the reduction of public health care costs.
It is very likely that the age-related loss of muscle proteins is aggravated by a decreased arterial availability of nutrients. The amino acid (AA) bioavailability depends firstly on the nature and quantity of ingested proteins and secondly on the metabolic activity of the tissues using AA and competing with the muscle for nutrients use. Among these competitors, tissues from the splanchnic area (gut and liver) play a key role. Any specific increased utilization of one or several available AA by these organs will necessarily negatively impact on muscle protein anabolism.
My research program focuses on the fate of dietary protein within the digestive tract (digestibility, digestion rate, released peptides), and the metabolism of amino acids within the gut and the liver.
Didier Rémond: PhD (Animal Physiology),
Research Director at INRA.
With 12 years of experiment in the area of ruminant nutrition, I have acquired a good knowledge of plant foodstuffs, and an integrated view of the food chain. I am now working, since 15 years, in nutrition, and protein metabolism, in humans.
- Ruminant nutrition: protein digestion, amino acid absorption, N recycling, microbial protein synthesis
- Human nutrition: protein quality evaluation (amino acid composition, digestibility, digestion rate, bioactive peptides), impact of food processing on protein quality, amino acid metabolism in the gut, inter-organ fluxes of amino acids.
- Experimental approaches: in vivo studies in human or animals (ruminant, pig, minipig, rat), focussing on quantitative and dynamics measurements of digestive and blood fluxes of nutrients: 1/ surgical implantation of digestive cannula, and vascular catheters, 2/ measurement of the digestive and blood fluxes, 3/ use of 15N labelled protein sources.
- Coordinator of a regional program on the nutritional prevention of sarcopenia (PRENUSA, 2011-2015, 625 k€, 8 partners).
- Involved as task leader in the ANR program PRONUTRIAL (2010-2013), and in the European FP7 project DREAM (2009-2013).
- French representative in the management committee of the INFOGEST COST action (European Union, FA1005, 2011-2015).
- In charge of several research contracts with private companies (Limagrain, Nestlé, Tereos …).
- Coordinator of a project on rapeseed protein valorization in human nutrition, supported by the SAS PIVERT (2015-2018, 582 k€, 4 partners).
- Chair of the organizing committee of the 61th ICOMST (2015).