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Unité de Nutrition Humaine

Zone de texte éditable et éditée et rééditée

Actualités de l'équipe


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Barre OrangeJPG



Aging research reviews

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project


Peripheral Blood Mononuclear CellMetabolism Acutely Adapted to Postprandial Transition and Mainly Reflected Metabolic Adipose Tissue Adaptations to a High-Fat Diet in Minipigs

label FRM

Novembre 2018 : Cérémonie de labellisation de l’équipe iMPROVINg par la Fondation pour la Recherche Médicale

these JAniort

Novembre 2018, soutenance de thèse de Julien Aniort, encadré par Daniel Taillandier

"Mécanismes de l’Atrophie Musculaire au Cours de l’Insuffisance Rénale"

J Cachexia SM

A muscle-specific MuRF1-E2 network requires stabilization of MuRF1-E2 complexes by telethonin, a newly identified substrate


Early changes in tissue amino acid metabolism and nutrient routing in rats fed a high-fat diet: evidence from natural isotope abundances of nitrogen and carbon in tissue proteins


P-Probs :

Valoriser les protéines végétales destinées à prévenir les dysfonctionnements métaboliques chez les personnes âgées

Coordinateur: Didier Rémond


Efficience de la production de protéines alimentaires dans les régions tropicales humides : un compromis à l’échelle de la ferme, de l’animal et de la plante

Food function

A meal with mixed soy/whey proteins is as efficient as a whey meal in counteracting the aged-related muscle anabolic resistance only if protein content and leucine levels are increased

Food research International

Measuring the effects of in vitro mastication on bolus granulometry of shredded meat: A proposal for a new methodological procedure

JFN 2018 alain

Alain Bruhat

« Le sensing par GCN2 : la souris CARE-LUC, un outil pour visualiser l’activation de la voie GCN2-eIF2a-ATF4 »

JFN 2018 lydie

Lydie Combaret

« Protéines musculaires »



j nutr

Metabolomics Reveals that the Type of Protein in a High-Fat Meal Modulates Postprandial Mitochondrial Overload and Incomplete Substrate Oxidation in Healthy Overweight Men.


Food function

Effects of oat protein supplementation on skeletal muscle damage, inflammation and performance recovery following downhill running in untrained collegiate men


Journées Francophone de Nutrition

D. Dardevet


Journées Francophone de Nutrition

S. Polakof

Food function

Oral declines and mastication deficiencies cause alteration of food bolus properties.



Metabolic adaptations to HFHS overfeeding: how whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs.




Conférence"Alimentation, Santé et Plaisir "

Organisée par la Mutualité

D. Dardevet S. Polakof

Lyon, Septembre 2018, St Etienne, 16 Octobre 2018. Roanne 13 Novembre 2018


Une substitution de 70% des protéines de Lactosérum par des protéines de Soja permet de maintenir l’effet anabolique du repas dans le muscle squelettique du rat âgé

Food chemistry

Combined in vivo and in silico approaches for predicting the release of bioactive peptides from meat digestion

j nutr

Fructose Feeding during the Postabsorptive State Alters Body Composition and Spares Nitrogen in Protein-Energy-Restricted Old Rats


La Sarcopénie: l’ennemie de la mobilité et de l’indépendance chez la personne âgée !


I Papet

Mol food chem JPG

Opposite effects of the spinach food matrix on lutein bioaccessibility and intestinal uptake lead to unchanged bioavailability compared to pure lutein.


The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

Emergence 2017

Sergio Polakof

La métabolomique quantitative: une nouvelle approche pour explorer le métabolisme tissulaire


Daniel Taillandier Projet « MUSPARE » - Ciblage des enzymes d’ubiquitination responsables de l’atrophie musculaire : une nouvelle stratégie de lutte contre la perte de muscle

CaNutrition JPG

Time-course changes in circulating branched-chain amino acid levels and metabolism in obese Yucatan minipig


Food chemistry

The matrix of fruit & vegetables modulates the gastrointestinal bioaccessibility of polyphenols and their impact on dietary protein digestibility



Avril 2018 : L’équipe iMPROVINg vient d’être labellisée par la FRM pour le projet "Improving patient health by correcting amino acid/protein homeostasis dysregulation in chronic diseases" porté par P. Fafournoux


UNH  participe dans le cadre des villes Apprenantes UNECO:

La Viande, Mon Alliée Santé:

D. Rémond

Journal of physiology and biochemistry

Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients


Food function

Effect of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats, Modulation by rutin and other micronutrients




Pierre Fafournoux

   "Développement d’un nouveau système d’expression génique modulable par une intervention nutritionnelle et utilisable en thérapie génique"


Daniel Béchet :« TRANSMAG - Skeletal Muscle Magnesium Transporters Gene Expression Responsiveness to Low Magnesium Status »


Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case.


Conférence"Alimentation, Santé et Plaisir "

Organisée par la Mutualité

D. Dardevet S. Polakof

Valence, 5 juin 2018, Le puy en Velay, 27 juin 2018


Lydie combaret: Projet « PRIAM » Pré-conditionnement de la Réponse Intégrée au stress pour une meilleure Adaptation du Muscle squelettique chez la souris en apesanteur simulée





Optimisation de la préservation de la masse musculaire par une approche de chrono-nutrition protéino-énergétique dissociée des repas.Cas modèle : Personne âgée fragilisée

Coordinateurs du projet: S. Polakof,  D. Dardevet  et D. Béchet 


Daniel Taillandier "teleth-E2-MuRF1" « Role of E2 conjugating enzymes in the MuRF1-dependent targeting of telethonin in skeletal muscle »



Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats.


Free radical biologie and medecine

At same leucine intake, a whey/plant protein blend is not as effective as whey to initiate a transient post prandial muscle anabolic response during a catabolic state in mini pigs

Reactive oxygen species enhance mitochondrial function, insulin sensitivity and glucose uptake in skeletal muscle of senescence accelerated prone mice SAMP8



The influence of different diets on metabolism and atherosclerosis processes—A porcine model: Blood serum, urine and tissues 1H NMR metabolomics targeted analysis

Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps




The CCAAT/enhancer-binding protein-ATF response elements-luciferase mouse model, an innovative tool to monitor the integrated stress response pathway in vivo

Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response



Dairy Processing & rheological properties of wheat flour dough and bread containing high levels of soluble dietary fibres blends.


Metabolic adaptations to HFHS overfeeding: how whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs

In the elderly, meat protein assimilation from rare meat is lower than that from meat that is well done.


Critical food

Similarities and interactions between the ageing process and high chronic intake of added sugars

Dairy products and inflammation: A review of the clinical evidence


Critical food

Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?

Glucagon's effect on liver protein metabolism in vivo


Tuning transgene expression with an artificial diet: a compelling resource in gene therapy

Age-Dependent Control of Energy Homeostasis by Brown Adipose Tissue in Progeny Subjected to Maternal Diet–Induced Fetal Programming


Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells

Age-related changes in mastication.


Soluble milk proteins improve muscle mass recovery after immobilization-induced muscle atrophy in old rats but do not improve muscle functional property

Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice.

british_journal of nutrition

Dietary calcium impairs tomato lycopene bioavailability in healthy humans

Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids

représentants FRM

Cérémonie Label FRM

Ce Jeudi 8 novembre, la représentante locale de la FRM, Mme Echavidre, ainsi que le responsable des comités régionaux, M. Auriau, ont organisé...
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