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Unité de Nutrition Humaine

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Dr Christine MORAND

Directrice de Recherche (PhD - HDR)

Responsable de l'équipe NutriVasc
Christine Morand

Mots Clés:

Fonction vasculaire

Etude clinique

FMD

Contact

Email : christine.morand@inra.fr

Tel : +33(0)4 73 62 40 84

Dr Christine Morand leads the Diet, Plant food bioactives & Vascular Health research group (NutriVasc) of the Human Nutrition Unit. She is also member of Scientific Council of the Food Research Department at INRA.

She is working for 10 years in the field of Nutrition & Health to study the role of dietary polyphenols in the prevention of cardiovascular diseases through a translational approach.This research includes human intervention studies with non-invasive assessment of vascular function, supplementation studies in animal models of atherosclerosis and cell experiments on vascular and immune cells. Previously she developped research on the absorption and metabolism of polyphenols.

Presently, she chairs the European COST-Action POSITIVe (FA1403) that addresses the interindividual variation in bioavailability and bioactivity in response to the consumption of plant food bioactives in relation to cardiometabolic outcomes. This multidisciplinary scientific network involves more than 70 research institutions from 31 European countries (http://www6.inra.fr/cost-positive). 

Recent and ongoing projects

- Chair of the COST Action FA14013 - POSITIVe " Interindividual variation in response to plant food bioactives and determinants involved" (2014-18, 71 research institutions, 31 European  countries).

- PI of an INRA-Métaprogramme Grant: "Endothelial biomarkers as new predictive tools to identify the impact of diet on cardiovascular risk and on overall health status" (2013-14)

- Co-Investigator on a FP7 Grant: Targeted delivery of dietary flavanols for optimal human cell function: Effects on cardiovascular health (FLAVIOLA) (2009-13)

- PI of FDOC Grants (Florida Department of Citrus, Florida States, USA);

- (RFP 07-09): "Effects of flavonoids from grapefruit juice consumption on vascular function in post-menopausal women" (2011-14).

- (RFP 05-11): "Effect of the consumption of orange juice on vascular protection and immune function in healthy subjects – A human study on the specific contribution of orange flavanones » (2009-11).

- WP leader of a French National Research Agency Grant (ANR-06-PNRA-013): "Effect of a regular citrus fruit consumption on vascular protection" (2007-10).

Scientific animation

- 7th International Conference on Polyphenols and Health, Tours, France, 27-30th Oct 2015. (chair)

- 1st International workshop of the COST Action POSITIVe, Tours, France, 26-27th Oct 2015. (chair)

Publications

1. Habauzit V, Verny M, Milenkovic D, Barber-Chamoux N, Mazur A, Dubray C and Morand C. 2015. Flavanones protect from arterial stiffness in postmenopausal women consuming grapefruit juice for 6-months: A randomized controlled crossover trial. American Journal of Clinical Nutrition. May 27. pii: ajcn104646.

2. Morand C, Dubray C, Milenkovic D, Lioger D, Martin JF, Scalbert A, Mazur A. 2011. Hesperidin contributes to trhe vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr, 93, 73-80.

3. Milenkovic D, Deval C, Dubray C, Mazur A, Morand C. 2011. Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a controlled cross-over study. Plos ONE;6(11):e26669. Epub 2011 Nov 16

4. Coban D, Milenkovic D., Chanet A., Mazur A., Morand C. 2012. Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. Molecular Nutrition and Food Research 56(8):1270-81.

5. Chanet A, Milenkovic D, Claude S, Maier JAM, Khan M, Shinkaruk S, Bérard AM, Bennetau-Pelissero C, Mazur A, Morand C. 2013. Flavanone metabolites decrease monocyte adhesion to endothelial cells by modulating expression of related genes. B J Nutr. 21:1-12.

6. Milenkovic D, Jude B, Morand C. 2013. miRNA as molecular target of polyphenols underlying their biological effects. Free Radic Biol Med. Jun 7. [Epub ahead of print]