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Unité de Nutrition Humaine

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Publications récentes 2017-2018

Publication 2018


Peripheral Blood Mononuclear Cell Metabolism Acutely Adapted to Postprandial Transition and Mainly Reflected Metabolic Adipose Tissue Adaptations to a High-Fat Diet in Minipigs



Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics.

Food function

A meal with mixed soy/whey proteins is as efficient as a whey meal in counteracting the aged-related muscle anabolic resistance only if protein content and leucine levels are increased

Food research International

Measuring the effects of in vitro mastication on bolus granulometry of shredded meat: A proposal for a new methodological procedure

Aging research reviews

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project

nucleic acids research

HMDB 4.0: the human metabolome database for 2018


Substantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled Trial.


Breakthroughs in the Health Effects of Plant Food Bioactives: A Perspective on Microbiomics, Nutri(epi)genomics, and Metabolomics.


Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies.

Aging Disease

Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours

Cafree radical biology

Anthocyanins and their gut metabolites attenuate monocyte adhesion and transendothelial migration through nutrigenomic mechanisms regulating endothelial cell permeability

IJMS 2018 (Nutrivasc)

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

ABB 2018 Krga

Effects of anthocyanins and their gut metabolites on adenosine diphosphate-induced platelet activation and their aggregation with monocytes and neutrophils

J Gerontol Ser A 2018 Dalle

Muscle loss associated changes of oxylipin signatures during biological aging: an exploratory study from the PROOF cohort.

Food function

Effects of oat protein supplementation on skeletal muscle damage, inflammation and performance recovery following downhill running in untrained collegiate men.


Progesterone-associated arginine decline at luteal phase of menstrual cycle and associations with related amino acids and nuclear factor kB activation

Food toxicology

French infant total diet study: Exposure to selected trace elements and associated health risks

Food function

Effect of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats, Modulation by rutin and other micronutrients

Mol food chem JPG

Opposite effects of the spinach food matrix on lutein bioaccessibility and intestinal uptake lead to unchanged bioavailability compared to pure lutein


The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

j nutr

Metabolomics Reveals that the Type of Protein in a High-Fat Meal Modulates Postprandial Mitochondrial Overload and Incomplete Substrate Oxidation in Healthy Overweight Men

Journal of physiology and biochemistry

Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients


Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case.


Early changes in tissue amino acid metabolism and nutrient routing in rats fed a high-fat diet:

Food function

Oral declines and mastication deficiencies cause alteration of food bolus properties.

CaNutrition JPG

Time-course changes in circulating branched-chain amino acid levels and metabolism in obese Yucatan minipig

Food chemistry

The matrix of fruit & vegetables modulates the gastrointestinal bioaccessibility of polyphenols and their impact on dietary protein digestibility.

j nutr

Fructose Feeding during the Postabsorptive State Alters Body Composition and Spares Nitrogen in Protein-Energy-Restricted Old Rats

Food chemistry

Combined in vivo and in silico approaches for predicting the release of bioactive peptides from meat digestion

Food function

Beyond nutrient-based food indices: a data mining approach to search for a quantitative holistic index reflecting the degree of food processing and including physicochemical properties

Food function 2

Processing of oat: the impact on oat's cholesterol lowering effect

Crit Rev food

Influence of food structure on dairy protein, lipid and calcium bioavailability: A narrative review of evidence.


Metabolic adaptations to HFHS overfeeding: how whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs.

Publication 2017


Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction.

Ageing Res Rev

Nutrition for the ageing brain: Towards evidence for an optimal diet

Adv in Nutrition

Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved.

Krga FRBM 2018

Curcumin modulates endothelial permeability and monocyte transendothelial migration by affecting endothelial cell dynamics.

RMD open

Impact of gender on the response and tolerance to abatacept in patients with rheumatoid arthritis: results from the 'ORA' registry

GN 2018 (Nutrivasc)

A scheme for a flexible classification of dietary and health biomarkers

PNS 2018 (NutriVasc)

Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance.

GN 2018 (Nutrivasc)

Dietary and health biomarkers-time for an update.

j nutr

Supplementing Breakfast with a Vitamin D and Leucine-Enriched Whey Protein ..... Muscle Mass in Healthy Older Men.

molecular nutrition foos research

Fast digestive, leucine-rich, soluble milk proteins improve muscle protein anabolism, and mitochondrial function in undernourished old rats.


The Back Belief Questionnaire is efficient to assess false beliefs and related fear in low back pain populations: A transcultural adaptation and validation study

molecular nutrition foos research

Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.


Production of trans and conjugated fatty acids in dairy ruminants and their putative effects on human health: A review.

analytical bioanalytical chemistry

Evaluation of oxidized phospholipids analysis by LC-MS/MS


Vitamin D and walking speed in older adults: Systematic review and meta-analysis

american college of nutrition

Vitamin D and walking speed in older adults: Systematic review and meta-analysis

Biochemistry ceel biology

Create, run, share, publish, and reference your LC-MS, FIA-MS, GC-MS, and NMR data analysis workflows

cell death

Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death.

mass spectrometry

Myofiber metabolic type determination by mass spectrometry imaging


The future of metabolomics in ELIXIR

Clinical  medicine research

Body Composition Is Altered in Pre-Diabetic Patients With Impaired Fasting Glucose Tolerance: Results From the NHANES Survey.

frontiers in physiology

Early sepsis does not stimulate reactive oxygen species production and does not reduce cardiac function despite an increased inflammation status.

physiological reports

Strength Training Decreases Inflammation and Increases Cognition and Physical Fitness in Older Women with Cognitive Impairment

Nutrition research

Reduced neural responses to food cues might contribute to the anorexigenic effect of acute exercise observed in obese but not lean adolescents

journal of oncolgy

Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer.


In vitro and in vivo antioxidant potential of milks, yoghurts, fermented milks and cheeses: a narrative review of evidence


Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats.

Medical system

A Novel Smartphone Accelerometer Application for Low-Intensity Activity and Energy Expenditure Estimations in Overweight and Obese Adults. 


The influence of different diets on metabolism and atherosclerosis processes: A porcine model: Blood serum, urine and tissues 1H NMR metabolomics targeted analysis

Free radical biologie and medecine

Reactive oxygen species enhance mitochondrial function, insulin sensitivity and glucose uptake in skeletal muscle of senescence accelerated prone mice SAMP8.


At same leucine intake, a whey/plant protein blend is not as effective as whey to initiate a transient post prandial muscle anabolic response during a catabolic state in mini pigs

molecular nutrition foos research

Substantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomised Controlled Trial.

Critical food

Dairy products and inflammation: A review of the clinical evidence


Metabolic adaptations to HFHS overfeeding: how whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs 


In the elderly, meat protein assimilation from rare meat is lower than that from meat that is well done.


Daily Intake of Chlorogenic Acids from Consumption of Maté (Ilex paraguariensis A.St.-Hil.) Traditional Beverages.


Determination of serum albumin, analytical challenges: a French multicenter study.


Glucagon's effect on liver protein metabolism in vivo


Dairy Processing & rheological properties of wheat flour dough and bread containing high levels of soluble dietary fibres blends.


Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?


Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice.

Long-term improvement of breast cancer survivors' quality of life by a 2-week group physical and educational intervention: 5-year update of the 'PACThe' trial..

B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort.

Similarities and interactions between the ageing process and high chronic intake of added sugars.


WittyFit-Live Your Work Differently: Study Protocol for a Workplace-Delivered Health Promotion.

Nordic walking versus walking without poles for rehabilitation with cardiovascular disease: Randomized controlled trial.

Systems Metabolomics for Prediction of Metabolic Syndrome.

Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells.


Metabolomics, Nutrition, and Potential Biomarkers of Food Quality, Intake, and Health Status.

Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation.

Vitamin D supplementation restores the blunted muscle protein synthesis response in deficient old rats through an impact on ectopic fat deposition.

Long-term cost reduction of routine medications following a residential programme combining physical activity and nutrition in the treatment of type 2 diabetes: a prospective cohort study


A new equation based on the 6-min walking test to predict VO2peak in women with obesity.

The CCAAT/enhancer-binding protein-ATF response elements-luciferase mouse model, an innovative tool to monitor the integrated stress response pathway in vivo.

Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps.

The eMouveRecherche application competes with research devices to evaluate energy expenditure, physical activity and still time in free-living conditions.


Vitamin D and muscle trophicity.

Soluble milk proteins improve muscle mass recovery after immobilization-induced muscle atrophy in old rats but do not improve muscle functional property

Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice.

Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis.

 “Glutamine: Biochemistry, Physiology, and Clinical Applications"

Frequency of concomitant fibromyalgia in rheumatic diseases: Monocentric study of 691 patients.

[Tuning transgene expression with an artificial diet: a compelling resource in gene therapy]

Impact of Flavonols on Cardiometabolic Biomarkers:  A Meta-Analysis of Randomized Controlled Human  Trials to Explore the Role of Inter-Individual  Variability

Parution d’un ouvrage sous la direction de Dominique Meynial-Denis : “Glutamine: Biochemistry, Physiology, and Clinical Applications” (CRC Press)


Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response.


Age-related changes in mastication.


Dietary calcium impairs tomato lycopene bioavailability in healthy humans.


Effect of a 5-Month Worksite Physical Activity Program on Tertiary Employees Overall Health and Fitness.


Management of dyslipidemia in high-risk patients with recent-onset rheumatoid arthritis: targets still not met despite specific recommendations. Results from the ESPOIR cohort during the first five years of follow-up.

The degree of processing of foods which are most widely consumed by the French elderly population is associated with satiety and glycemic potentials and nutrient profiles.

Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study.

Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies.


DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: putative mechanisms through PPAR activation

Age-Dependent Control Of Energy Homeostasis by Brown Adipose Tissue in Progeny Subjected to
Maternal Diet-Induced Fetal Programming.

Sarcopenia in older mice is characterized by a decreased anabolic response to a protein meal.

Effect of reproductive ageing on pregnant mouse uterus and cervix

PG other lipid mediators

Insight into the contribution of isoprostanoids to the health effects of omega 3 PUFAs.


Impact of Flavonols on Cardiometabolic Biomarkers: A Meta‐Analysis of Randomized Controlled Human Trials to Explore the Role of Inter‐Individual Variability

Enhancement of Lytic Activity by Leptin Is Independent From Lipid Rafts in Murine Primary Splenocytes.